Asymmetric cyclopropa nation of optically active vinyl sulfoxides: A new synthetic approach to biologically active compounds

摘要

The influence of adjacent substituents on stereochemical course of cyclopropanation of vinyl sulfoxides with stabilized and nonstabilized ylides, as well as dependence on reaction conditions, was investigated. Application of optically active cyclopropanes obtained in the synthesis of conformationally constrained analogs of L-glutamic acid, the useful pharmacological tools in investigation of excitatory amine acid receptors, is presented.