Addition of Organolithium and Grignard Reagents to Pyrimidine-2(1H)-thione: Easy Access to 4-Substituted 3,4-Dihydropyrimidine-2(1 H)-thiones

摘要

Organolithium and Grignard reagents are added to pyrimidine-2(1H)-thione, yield_ing 4-substituted 3,4-dihydropyrimidine-2-(1H)-thiones. Since the synthetic proce_dure can be performed on a multigram scale, and since pyrimidine-2(1H)-thione as well as the majority of organometallic reagents are readily available, the pro_cess described provides an easy access and complementary to other methods to 4-substituted 3,4-dihydropyrimidine-2-(1H)-thiones.