Human body burdens of chemicals usedin plastic manufacture

摘要

In the last decades, the availability of sophisticated analytical chemistry techniques has facilitatedmeasuring trace levels of multiple environmental chemicals in human biological matrices (i.e. bio-monitoring) with a high degree of accuracy and precision. As biomonitoring data have becomereadily available, interest in their interpretation has increased. We present an overview on the useof biomonitoring in exposure and risk assessment using phthalates and bisphenol A as examplesof chemicals used in the manufacture of plastic goods. We present and review the most relevantresearch on biomarkers of exposure for phthalates and bisphenol A, including novel and mostcomprehensive biomonitoring data from Germany and the United States. We discuss several factorsrelevant for interpreting and understanding biomonitoring data, including selection of bothbiomarkers of exposure and human matrices, and toxicokinetic information.