Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry

Berm E.; Kok R.; Hak E.; Wilffert B.

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Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry

机译：老年精神病患者中去甲替林和文拉法辛使用者中CYP2D6基因型，表型与治疗药物浓度的关系

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Objectives: To determine relations between drug concentrations and the cytochrome P450-CYP2D6 genotype or phenotype among elderly patients treated with nortriptyline or venlafaxine.

机译：目的：确定在接受去甲替林或文拉法辛治疗的老年患者中，药物浓度与细胞色素P450-CYP2D6基因型或表型之间的关系。

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《Pharmacopsychiatry》 |2016年第5期|共5页
作者
Berm E.; Kok R.; Hak E.; Wilffert B.;
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正文语种 eng
中图分类精神病学;
关键词
depression; genetics; cytochrome P450 (CYP) enzymes; venlafaxine; nortriptyline;

机译：抑郁;遗传学;细胞色素P450（CYP）酶;文拉法辛;去甲替林;

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1. Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry [J] . Berm E., Kok R., Hak E., Pharmacopsychiatry . 2016,第5期

机译：老年精神病患者中去甲替林和文拉法辛使用者中CYP2D6基因型，表型与治疗药物浓度的关系
2. Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups [J] . WaadeR.B., HermannM., MoeH.L., European journal of clinical pharmacology . 2014,第8期

机译：不同CYP2D6和CYP2C19基因型亚组血清血清浓度对血清浓度的影响
3. Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients [J] . Haslemo Tore, Eliasson Erik, Jukic Marin M., British Journal of Clinical Pharmacology . 2019,第1期

机译：CYP2D6 * 41载体与CYP2D6 * 9或CYP2D6 * 10的载体中测量的CYP2D6新陈代谢测量的CYP2D6新陈代谢测量：来自1003种基因斯堪纳维亚患者的治疗药物监测数据的研究
4. Influence of hepatitis C virus genotypes and F protein on outcome of HCV infection among injection drug users [C] . Yun Zhang, Jingjing Yang, Haopeng Wang, International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：丙型肝炎病毒基因型和F蛋白对注射吸毒者HCV感染结局的影响
5. Hepatitis C infection in injection drug users from southern China: Low viral clearance, multiple genotypes and mixed genotype infections. [D] . Garten, Rebecca JoAnne. 2005

机译：中国南部注射吸毒者的丙型肝炎感染：病毒清除率低，多种基因型和混合基因型感染。
6. CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry [O] . Espen Molden, Marin M. Jukić 2021

机译：CYP2D6减少函数变体和基因型/基因型/表型翻译CYP2D6中间代谢剂：对精神病学中的个性化药物给药的影响
7. Relation between genotype, phenotype and therapeutic drug concentrations of nortriptyline or venlafaxine users in old age psychiatry [O] . Berm, E.J.J., Kok, R.M., Hak, E., 2015

机译：去甲替林或文拉法辛使用者在老年精神病患者的基因型，表型与治疗药物浓度之间的关系

Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry

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