Serotonin syndrome with severe hyperthermia after ingestion of tranylcypromine combined with serotonin reuptake inhibitors and tyramine-rich food in a case of suicide.

摘要

The monoamine oxidase inhibitor (MAO-I) tranylcypromine was introduced about 50 years ago. It has been used for a long time as a third-line antidepressant for treatment-resistant depression. The blood plasma half-life of tranylcypromine is relatively short (1.5-3 h), but its biological effects last considerably longer. The combination of MAO-I with drugs which enhance the activity of the serotonergic system can result in a severe serotonin syndrome [2] with malignant hyperthermia syndrome [1,3].