Vagus nerve stimulation in a patient with Gilles de la Tourette syndrome and major depression.

摘要

Gilles de la Tourette Syndrome (GTS) is a chronic disease characterized by motor and vocal tics , Current medical therapy includes dopamine receptor antagonists, mainly atypical antip-sychotics [13]. We report a case in which a patient with therapy-resistant major depression and GTS syndrome was successfully treated with vagus nerve stimulation (VNS). He has given informed consent to be decsribed in this communication. A 63-year-old man, grown up in Germany, had been diagnosed with Gilles de la Tourette syndrome since the age of 16 years with motor tics (head jerks, shoulder jerks, facial tics, tapping) and echolalia. He was treated with olanzapine (dosage 5-20 mg), aripiprazole (7.5-15mg) and citaloprame (20-60mg) without success.