The 5-HT_(1A) receptor C( 1019)G polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation

摘要

Introduction: Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 min, and has been postulated as a neurobiological dysfunction related to diminished serotonergic neurotransmission with 5-HT_(1A) receptor hyperfunction and 5-HT_(2C) hypofunction. Aim: To investigate the relationship between 5-HT_(1A) receptor gene (HTR_(1A))-C(1019)G promoter polymorphism and IELT in men with LPE. This polymorphism is known to increase 5-HT_(1A) receptor expression. Methods: A prospective study was conducted in 54 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1 -month period. All men were genotyped for HTR_(1A) gene polymorphism. Allele frequencies and genotypes of C and G variants of HTR_(1A) polymorphism were determined. Association between CC, CG, and GG genotypes and the IELT in men with LPE were investigated.