Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations

Xie Tian; Taylor Lynne S.

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Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations

机译：用聚合物组合物配制的高载药量塞来昔布无定形固体分散体的溶解性能

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The aims of this study were twofold. First, to evaluate the effectiveness of selected polymers in inhibiting solution crystallization of celecoxib. Second, to compare the release rate and crystallization tendency of celecoxib amorphous solid dispersions (ASDs) formulated with a single polymer, or binary polymer combinations.

机译：这项研究的目的是双重的。首先，评估所选聚合物在抑制塞来昔布溶液结晶方面的有效性。其次，比较用单一聚合物或二元聚合物组合配制的塞来昔布无定形固体分散体（ASD）的释放速率和结晶趋势。

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《Pharmaceutical research》 |2016年第3期|共12页
作者
Xie Tian; Taylor Lynne S.;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
amorphous solid dispersion; crystallization; dissolution; supersaturation;

机译：非晶态固体分散体;结晶;溶解;过饱和;

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专利

1. Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations [J] . Xie Tian, Taylor Lynne S. Pharmaceutical research . 2016,第3期

机译：用聚合物组合物配制的高载药量塞来昔布无定形固体分散体的溶解性能
2. Amorphous Stabilization and Dissolution Enhancement of Amorphous Ternary Solid Dispersions: Combination of Polymers Showing Drug-Polymer Interaction for Synergistic Effects [J] . Prasad Dev, Chauhan Harsh, Atef Eman Journal of pharmaceutical sciences. . 2014,第11期

机译：非晶稳定和溶解增强的三元固体分散体：聚合物的组合显示药物-聚合物相互作用的协同作用。
3. Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions [J] . Knopp Matthias Manne, Nguyen Julia Hoang, Becker Christian, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2016,第Null期

机译：聚合物分子量对塞来昔布：PVP无定形固体分散体体外溶解行为和体内性能的影响
4. Dissolution Enhancement of the Poorly Water Soluble Drug by Solid Dispersion with a Novel Polymeric Solubilizer (Soluplus ) [C] . Han-Pin Lira, Yidan Lan, David Bigio, Annual meeting exposition of the Controlled Release Society . 2010

机译：新型聚合物增溶剂（Soluplus）通过固体分散增强难溶性药物的溶解度
5. Roles of Surfactant and Binary Polymers on Dissolution Enhancement of BCS II Drugs from Nanocomposites and Amorphous Solid Dispersions [D] . Rahman, Md. Mahbubur. 2019

机译：表面活性剂和二元聚合物对纳米复合材料和无定形固体分散体溶解增强的作用
6. Impact of HPMCAS on the Dissolution Performance of Polyvinyl Alcohol Celecoxib Amorphous Solid Dispersions [O] . Marius Monschke, Karl G. Wagner 2020

机译：HPMCA对聚乙烯醇CELECOXIB无定形固体分散体的溶出性能影响
7. Injection moulded controlled release amorphous solid dispersions: Synchronized drug and polymer release for robust performance [O] . Shivprasad Deshmukh, Anant Paradkar, Susanna Abrahmsén-Alami, 2020

机译：注塑控制释放无定形固体分散体：用于鲁棒性能的同步药物和聚合物释放

Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations

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