Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

Lovalenti Phillip M.; Anderl Jeff; Yee Luisa; Van Nguyen; Ghavami Behnaz; Ohtake Satoshi; Saxena Atul; Voss Thomas; Vu Truong-Le

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Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

机译：通过冷冻干燥，喷雾干燥和泡沫干燥来稳定活的减毒流感疫苗

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摘要

The goal of this research is to develop stable formulations for live attenuated influenza vaccines (LAIV) by employing the drying methods freeze drying, spray drying, and foam drying.

机译：这项研究的目的是通过采用冷冻干燥，喷雾干燥和泡沫干燥的干燥方法，为减毒活流感疫苗（LAIV）开发稳定的制剂。

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来源
《Pharmaceutical research》 |2016年第5期|共17页
作者
Lovalenti Phillip M.; Anderl Jeff; Yee Luisa; Van Nguyen; Ghavami Behnaz; Ohtake Satoshi; Saxena Atul; Voss Thomas; Vu Truong-Le;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
Attenuated; Drying; Influenza; Stability; Vaccine;

机译：减毒;干燥;流行性感冒;稳定性;疫苗;

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专利

1. Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying [J] . Lovalenti Phillip M., Anderl Jeff, Yee Luisa, Pharmaceutical research . 2016,第5期

机译：通过冷冻干燥，喷雾干燥和泡沫干燥来稳定活的减毒流感疫苗
2. Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice [J] . Amorij JP, Saluja V, Petersen AH, Vaccine . 2007,第52期

机译：通过喷雾冷冻干燥制备的菊粉稳定的流感亚单位疫苗的肺部递送可诱导BALB / c小鼠的全身性，粘膜体液以及细胞介导的免疫反应
3. Physical and immunogenic stability of spray freeze-dried influenza vaccine powder for pulmonary delivery: Comparison of inulin, dextran, or a mixture of dextran and trehalose as protectants [J] . MurugappanS., PatilH.P., KanojiaG., European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2013,第3aPta1期

机译：用于肺部递送的喷雾冷冻干燥流感疫苗粉末的物理和免疫原性稳定性：菊粉，右旋糖酐或右旋糖酐和海藻糖混合物作为保护剂的比较
4. Development of Inhalable Dry Gene Powders for Pulmonary Drug Delivery by Spray-Freeze-Drying [C] . Edina Vranic, Merima Sirbubalo, Amina Tucak International Conference on Medical and Biological Engineering . 2020

机译：喷涂干燥肺药可吸入干基因粉末的开发
5. A novel spray-drying process to stabilize glycolate oxidase and catalase in Pichia pastoris and optimization of pyruvate production from lactate using the spray-dried biocatalyst. [D] . Glenn, James Huston, IV. 2009

机译：一种新型喷雾干燥工艺，用于稳定巴斯德毕赤酵母中的乙醇酸氧化酶和过氧化氢酶，并使用喷雾干燥的生物催化剂优化乳酸中丙酮酸的生产。
6. A Comparison of Microfluidic-Jet Spray Drying Two-Fluid Nozzle Spray Drying and Freeze-Drying for Co-Encapsulating β-Carotene Lutein Zeaxanthin and Fish Oil [O] . Yongchao Zhu, Yaoyao Peng, Jingyuan Wen, 2021

机译：微流体喷射喷雾干燥双流体喷嘴喷雾干燥和冷冻干燥的比较用于共同包封β-胡萝卜素叶黄素玉米黄质和鱼油
7. Comparison of blueberry powder produced via foam-mat freeze-drying versus spray-drying: evaluation of foam and powder properties [O] . Darniadi, S, Ho, P, Murray, BS 2017

机译：通过泡沫垫冷冻干燥与喷雾干燥生产的蓝莓粉末的比较：泡沫和粉末性质的评价
8. Production of Freeze-Dried Pleuropneumonia Vaccine, and a Mixed Rinderpest-Pleuropneumonia Vaccine at the Central Veterinary Laboratory at Bamako, Republic of Mali [R] . Provost, A. 1988

机译：在马里共和国巴马科中央兽医实验室生产冻干胸膜肺炎疫苗和混合牛瘟 - 胸膜肺炎疫苗

Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

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