Preparation, in vitro characterization and in vivo release of naproxen loaded in poly-caprolactone nanoparticles.

Mainara Rangel Rodrigues; Cintia Maria Lanzarini; Eduardo Ricci-Junior

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Preparation, in vitro characterization and in vivo release of naproxen loaded in poly-caprolactone nanoparticles.

机译：载于聚己内酯纳米颗粒中的萘普生的制备，体外表征和体内释放。

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Naproxen was loaded in poly-caprolactone (PCL) nanoparticles as an implantable sustained release system to prolong its anti-inflammatory activity. Naproxen-loaded nanoparticles were produced with the following characteristics: Nanometric size (

机译：将萘普生装在聚己内酯（PCL）纳米颗粒中，作为可植入的缓释系统，以延长其抗炎活性。载有萘普生的纳米颗粒具有以下特征：纳米尺寸（<？300？nm），ζ负电势，低多分散指数（<？0.1），令人满意的包封效率，低水含量（<？1％）和球形形状。体外萘普生释放曲线得以维持，动力学遵循Higuchi模型。选择含有约12.5％（w / w）萘普生的PCL纳米颗粒（样品A3）用于大鼠稳定性和体内释放的补充研究。在稳定性研究过程中，纳米颗粒未发生变化。体内释放持续了一个月。因此，纳米颗粒显示出潜力，可作为用于慢性炎性疾病的可植入缓释系统。

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《Pharmaceutical development and technology》 |2011年第1期|共10页
作者
Mainara Rangel Rodrigues; Cintia Maria Lanzarini; Eduardo Ricci-Junior;
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1. Preparation, in vitro characterization and in vivo release of naproxen loaded in poly-caprolactone nanoparticles. [J] . Mainara Rangel Rodrigues, Cintia Maria Lanzarini, Eduardo Ricci-Junior Pharmaceutical development and technology . 2011,第1期

机译：载于聚己内酯纳米颗粒中的萘普生的制备，体外表征和体内释放。
2. Polyorganophosphazene microspheres for drug release: polymer synthesis, microsphere preparation, in vitro and in vivo naproxen release [J] . Veronese FM., Caliceti P., De Filippis P., Journal of Controlled Release: Official Journal of the Controlled Release Society . 1998,第3期

机译：用于药物释放的聚有机磷腈微球：聚合物合成，微球制备，萘普生的体内和体外释放
3. Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats [J] . Md Khalid Anwer, Muqtader Mohammad, Essam Ezzeldin, International Journal of Nanomedicine . 2019,第1期

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4. Release Profile, In Vitro and In Vivo Response to Carbon Monoxide Releasing Molecules Loaded within Electrospun Scaffolds [C] . Kenyatta S. Washington, Aatish V. Patel, Nawodi Abeyrathna, Society for Biomaterials annual meeting and exposition . 2017

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5. Preparation and in vitro/in vivo evaluation of sustained release AZT-loaded microspheres. [D] . Abu Izzah, Khawlah Abdullah. 1996

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6. Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats [O] . Md Khalid Anwer, Muqtader Mohammad, Essam Ezzeldin, 2019

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7. Preparation and characterization of cefditoren pivoxil-loaded liposomes for controlled in vitro and in vivo drug release [O] . N. C. Sarada, G Venugopala, R Lakshmipathy 2015

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Preparation, in vitro characterization and in vivo release of naproxen loaded in poly-caprolactone nanoparticles.

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