Complexation of cell-penetrating peptide-polymer conjugates with polyanions controls cells uptake of HPMA copolymers and anti-tumor activity.

Yosi Shamay; Lina Shpirt; Gonen Ashkenasy; Ayelet David

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Complexation of cell-penetrating peptide-polymer conjugates with polyanions controls cells uptake of HPMA copolymers and anti-tumor activity.

机译：细胞穿透肽-聚合物共轭物与聚阴离子的络合可控制细胞对HPMA共聚物的摄取和抗肿瘤活性。

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The gradual release of P-R8 from P-R8-DOX/PGA may improve the therapeutic efficacy of water-soluble based nanomedicines for the treatment of solid lung tumors.

机译：从P-R8-DOX / PGA逐渐释放P-R8可以提高水溶性纳米药物治疗实体肺肿瘤的疗效。

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《Pharmaceutical research》 |2014年第3期|共12页
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Yosi Shamay; Lina Shpirt; Gonen Ashkenasy; Ayelet David;
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正文语种 eng
中图分类生药学（天然药物学）;
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1. Complexation of cell-penetrating peptide-polymer conjugates with polyanions controls cells uptake of HPMA copolymers and anti-tumor activity. [J] . Yosi Shamay, Lina Shpirt, Gonen Ashkenasy, Pharmaceutical research . 2014,第3期

机译：细胞穿透肽-聚合物共轭物与聚阴离子的络合可控制细胞对HPMA共聚物的摄取和抗肿瘤活性。
2. Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization [J] . Acta biomaterialia . 2020,第期

机译：基于HPMA共聚物缀合物的高效抗肿瘤纳米核苷酸通过受控筏聚合制备的吡咯比蛋白
3. Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity [J] . Mrkvan T, Sirova M, Etrych T, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2005,第1期

机译：基于HPMA共聚物结合物的pH值控制的阿霉素化学疗法可触发抗肿瘤免疫力
4. Shape Effects of Nanoparticles Conjugated with Cell-Penetrating Peptide (HIV Tat PTD) on CHO Cell Uptake [C] . Ke Zhang, Zhiyun Chen, David S. Germack PMSE Symposia . 2007

机译：纳米颗粒与细胞穿透肽（HIV TAT PTD）缀合物对CHO细胞摄取的形状效应
5. The Use of HPMA Copolymer Conjugates for the Intracellular Targeting of Anticancer Drugs [D] . Callahan, Jon Doyle. 2017

机译：HPMA共聚物结合物用于抗癌药物的细胞内靶向
6. Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances [O] . Ehud Segal, Huaizhong Pan, Liat Benayoun, -1

机译：增强靶向纳米甲基HPMA共聚物-Alendronate-TNP-470缀合物的抗肿瘤活性和安全性曲线治疗骨恶性肿瘤
7. Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation [O] . E. Koziolová, D. Machová, R. Pola, 2016

机译：通过PH敏感的间隔物形成Ritonavir的胶束形成HPMA共聚物缀合物，其具有改进的细胞摄取，设计用于增强的肿瘤积累

Complexation of cell-penetrating peptide-polymer conjugates with polyanions controls cells uptake of HPMA copolymers and anti-tumor activity.

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