Search for new drugs Synthesis and antiseptic and antidote activity of polyhexamethyleneguanidine hydroxyethylidenediphosphonate salt

摘要

The synthesis and characterization of the new drug polyhexamethyleneguanidine hydroxyethylidenediphosphonate salt are presented. Its bacteriological activity is comparable to that of previously obtained polyhexamethyleneguanidine salts and higher than that of already known chlorhexidine digluconate while its toxic effect is lower. A specific feature is that aqueous solutions of this drug help to eliminate heavy metals from warm-blooded animals. Thus, polyhexamethyleneguanidinium hydroxyethylidenediphosphonate can be used as a cleansing, antiseptic, and sterilizing agent for treating pyoinflammatory processes, purifying water in water-cycling systems, and resolving antidote problems.