DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY EXTRACTION CAPACITY OF MONO- AND BIPHASIC SOLVENT SYSTEMS FOR ISOLATING FLAVONOIDS FROM TRIFOLIUM PRATENSE HERBS

摘要

Flavonoids are the principal active substances of Trifolium pratense. Various researchers have shown that the total flavonoid preparation and total isoflavones of red clover could lower the cholersterol content in blood by more than 50% for experimental hypercholesterolemia and atherosclerosis in animal tests [1], exhibit anti-arrhythmic activity for arrhythmia [2], and stimulate peristalsis of the intestinal tract [3]. Thus, total flavonoids of T. pratense are promising substances for pharmaceutical use. Herein we study the possibility of increasing the yield of flavonoids from raw material by selecting the optimum extractant for their extraction. Aqueous ethanol solutions or hot water is used most often to produce extracts of T. pratense herb. Alcohol of various concentrations and water extract most flavonoids [4].