Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs

Bozhok T. S.; Kalinichenko E. N.; Kuzmitskii B. B.; Golubeva M. B.

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Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs

机译：氮杂胞苷核苷类似物的合成，水解稳定性和抗白血病活性

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摘要

New azacytidine nucleoside analogs with modified carbohydrate moieties were synthesized. Screening identified a highly active 2'-fluoro-containing azacytidine analog that could potentially be of interest as an agent for treating acute myelogenous leukemia and myelodysplastic syndrome.

机译：合成了具有修饰的碳水化合物部分的新氮杂胞苷核苷类似物。筛选确定了一种高活性的含2'-氟氮杂胞苷类似物，作为治疗急性骨髓性白血病和骨髓增生异常综合症的药物可能引起人们的兴趣。

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《Pharmaceutical Chemistry Journal》 |2016年第12期|共6页
作者
Bozhok T. S.; Kalinichenko E. N.; Kuzmitskii B. B.; Golubeva M. B.;
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正文语种 eng
中图分类药学;
关键词
myelodysplastic syndrome; azacytidine; glycosylation; fluoro-deoxynucleosides; hydrolytic stability; antileukemic activity;

机译：骨髓增生异常综合症;氮胞苷;糖基化;氟脱氧核苷;水解稳定性;抗白血病活性;

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1. Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs [J] . Bozhok T. S., Kalinichenko E. N., Kuzmitskii B. B., Pharmaceutical Chemistry Journal . 2016,第12期

机译：氮杂胞苷核苷类似物的合成，水解稳定性和抗白血病活性
2. Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs [J] . Bozhok T. S., Kalinichenko E. N., Kuzmitskii B. B., Pharmaceutical Chemistry Journal . 2016,第12期

机译：氮杂胞苷核苷类似物的合成，水解稳定性和抗血清血肿活性
3. Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs [J] . Bozhok T. S., Kalinichenko E. N., Kuzmitskii B. B., Pharmaceutical Chemistry Journal . 2015,第12期

机译：氮杂胞苷核苷类似物的合成，水解稳定性和抗血清血肿活性
4. Structure-Cytotoxicity/Antiviral Activity Relationship Studies of Nucleoside Analogs Using Structure-Activity Maps [C] . Ravi R. Parakulam, Mathew L. Lesniewski, Michael A. Marquis II, AAAI Symposium . 1999

机译：结构 - 细胞毒性/抗病毒活性关系使用结构 - 活动图的核苷类似物的关系研究
5. Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant. Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation [D] . Bluemling, Gregory Richard 2011

机译：第一部分：模拟AZT抑制K65R HIV-1逆转录酶突变体的环丁基核苷类似物的合成。第二部分：截短雷公藤甲素类似物的合成和评估，以抑制慢性炎症
6. Synthesis antiviral activity and stability of nucleoside analogs containing tricyclic bases [O] . Franck Amblard, Emilie Fromentin, Mervi Detorio, -1

机译：含有三环基碱的核苷类似物的合成抗病毒活性和稳定性
7. Radical deoxygenation of tert-alcohols in 2'-branched-chain sugar pyrimidine nucleosides: Synthesis and antileukemic activity of 2'-deoxy-2'(S)-methylcytidine. [O] . Akira Matsuda, Kenji Takenuki, Hiroko Itoh, 1987

机译：叔醇在2'-支链糖嘧啶核苷中的根基脱氧：2'-脱氧-2'（S） - 甲基胞苷的合成和抗血糖活性。
8. Synthesis, Hydrolytic Refractivity and Initial Bioevaluation of (R)-Etomidate Analogs. Part 1. Synthesis and Hydrolytic Refractivity of (R)-Etomidate Analogs [R] . Benecke, H. P., Harsh, S. S., King, J. W. 1987

机译：（R） - 依托咪酯类似物的合成，水解折射率和初始生物评价。第1部分（R） - 依托咪酯类似物的合成和水解折射率

Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs

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