Synthesis and biological activity of organosilicontitanium glycerohydrogels

摘要

A series of organosilicontitanium (OST) glycerohydrogels with the general formula 2Si(C3H7O3)4 ? Ti(C 3H7O3)4 ? xC3H 8O3 ? yH2O (where 9 ≤ x ≤ 30 and 60 ≤ y ≤ 120) were synthesized and some of their pharmacological properties were studied. High percutaneous activity of the compounds was revealed by measuring the diffusion of sodium diclofenac through intact skin membranes in vitro. It was established that all of the synthesized substances are nontoxic. The wound-healing and antioxidant properties of the glycerohydrogels were studied. The experimental results show that OST glycerohydrogels can be recommended for further testing as effective percutaneous vehicles of medicines with wound-healing, burn-healing, and antioxidant action.