SYNTHESIS AND BIOLOGICAL ACTIVITY OF N-[3-(4-SUBSTITUTED PHENYL)-3-HYDROXYPROPYL]VALINES AND -TRYPTOPHANS, AND 3-{[3-HYDROXY-3-(4-SUBSTITUTED PHENYL)PROPYL]AMINO}-3-PHENYLPROPANOIC ACIDS

摘要

Reduction of N-[P-(4-substituted benzoyl)ethyl]amino acids with sodium borohydride yielded arylaliphatic aminopropanols containing amino acid fragments - N-[3-(4-substituted phenyl)-3-hydroxypropyl]valines, -tryptophans, and 3-{[3-hydroxy-3-(4-substitutedphenyl)propyl]amino}-3-phenylpropanoic acids. Studies of the biological activities of these compounds showed that some had anti-inflammatory and anticonvulsive activities.