MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISMS OF DRUG ACTION

摘要

The pharmacokinetics of two tablet formulations of amiodarone - Amiodarone and Amiodaron-Akri - were studied in 12 rabbits and 18 healthy human volunteers after single p.o. doses of 200 mg. A highly statistically significant correlation was found between plasma amiodarone concentrations in rabbits and volunteers (r = 0.8263, p < 0.001). Normalized C_max and AUC values were significantly greater in volunteers than rabbits, while specific V_Z and Cl_t values were lower and MRT was significantly higher; rate coefficients of absorption and measures of relative bioavailability showed no statistically significant differences between rabbits and healthy humans.