Ketotifen overdose in infancy associated with development of epilepsy and mild mental retardation

摘要

Overdose of classical antihistamines (i.e. diphenhydramine) occasionally triggers convulsions and lethal toxic encephalopa-thy with convulsions, especially in children under the age of 2 years.1 These side-effects may be associated with the cholinergic action of classical antihistatnines.1 Overdose of ketotifen, a selective Hi antagonist, has been Sported to cause cardiovascular side-effects and convulsions without sequelae.2 This study shows that overdose of ketotifen is suggested to result in toxic encepha-lopathy followed by localization-related epilepsy and mild mental retardation.