* GAS is a common cause of upper respiratory tract and skin infections.* Based on strong research evidence, (1) throat culture is the gold standard for diagnosing GAS pharyngitis.* Based on strong research evidence, (1) oral penicillin V K is the antibiotic treatment of choice for GAS pharyngitis because of its efficacy, safety, and narrow spectrum.* Based on strong research evidence, (2) primary prevention of complications of GAS such as ARF involves prompt diagnosis and antibiotic treatment of GAS pharyngitis.* GAS nonsuppurative and suppurative complications may occur and are mediated by interactions between GAS antigens or exotoxins and the patient's immunesystem.
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