Inflammatory bowel disease.

摘要

IBD is a complex, multifactorial disease characterized by chronic inflammation in the intestinal tract of a genetically predisposed host. The spectrum of IBD in children primarily includes ulcerative colitis (UC) and Crohn disease (CD). With pediatric patients now accounting for 20% to 25% of newly diagnosed cases, it is becoming increasingly important for pediatricians to recognize the symptoms of IBD. (1) In this review, we discuss the epidemiology, clinical presentation, diagnosis, and complications of IBD, with specific emphasis on growth failure and pubertal delay because these are unique manifestations in children. We also describe newer, less invasive diagnostic techniques and current trends in management and advances in the pharmacologic treatment of affected children.