Hemolytic-Uremic Syndrome

摘要

Hemolytic-uremic syndrome (HUS), the triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency, is the leading cause of renal failure in the United States in previously healthy children, in particular those younger than 3 years of age. There are two broad etiologic categories: typical HUS (with diarrhea, or D+) and atypical HUS (without diarrhea, or D-). Some 90% of HUS in the United States is classified as D+, and most cases are caused by shiga-toxin-producing strains of Escherichia coli (STEC), most often the O157:H7 subtype.