Comments on the diagnosis and management of CLOVES syndrome.

摘要

I read with interest the case report by Harit and Ag-garwal (1) in which the authors presented a male neonate with asymmetric lower limb overgrowth and vascular anomalies. The authors suggested the diagnosis of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome and provided a brief discussion of this rare disorder. While I agree with the diagnosis given to this child, I would like to discuss several assertions I disagree with in this report.1. The cardinal features of CLOVES syndrome are truncal lipomatous masses, vascular malformations, and cutaneous and acral/musculoskeletal anomalies (2,3). Of note, the syndrome was described independently and simultaneously by Sapp et al (2) and Alomari (3-5). Our initial cohort of 18 patients showed that spinal involvement (e.g., scoliosis, spinal metameric high flow lesions, neural tube defects, tethered cord, and spasticity) and skeletal anomalies involving the trunk and both upper and lower extremities were among the most frequent findings in CLOVES syndrome (3).