Postvaccination morphea profunda in a child.

摘要

We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with "solitary morphea profunda." A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9?months duration. The lesion had appeared 3?months after a third dose of diphtheria-tetanus-pertussis vaccine. Cutaneous examination showed an induration of 7 × 7?cm with an "orange peel" texture after pinching the skin. Histologic examination confirmed the diagnosis of MP. Systemic steroids (1?mg/kg/day) led to the stabilization of the lesion. After 4?months of treatment, we began the concomitant use of oral methotrexate (10?mg/wk) for 2?months. Methotrexate was then continued alone for 10?months, leading to a significant regression of the induration with no relapse.