Effect of Tooth Mousse on Streptococcus Mutans in the Plaque of High Caries-risk Preschool Children: A Triple-Blind, Randomized Clinical Trial

摘要

Purpose: Control of Streptococcus mutans can prevent caries in high-risk preschool children. The purpose of this study was to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) on Streptococcus mutans in the plaque of high-risk preschool children. Methods: A triple blind, randomized, controlled clinical trial included 40 healthy three- to five-year-olds with at least one white spot lesion. They were randomized into test (daily applications of GC Tooth Mousse:CPP-ACP) and control groups (placebo mousse). Both groups received health education. Plaque samples were collected at baseline and after 15 days and cultured on Mitis Salivarius Agar. Percent reduction in S mutans count was calculated and compared between groups using t-test. Results: Percent reduction of S mutans in the test group was slightly higher than in the control group (59 percent and 52 percent) but not significantly different after 15 days (P=0.27), with both groups showing a significant reduction from baseline (P<0.0001). Conclusions: Casein phosphopeptide amorphous calcium phosphate reduced Streptococcus mutans in the plaque of preschool children with noncavitated lesions after two weeks of daily application compared to baseline. It was not, however, significantly different from the reduction occurring after only a single session of health education.