Oswald T. Avery: nobel laureate or noble luminary?

摘要

In 1944, Oswald T. Avery and his associates reported that DNA was the chemical substance acting to genetically transform species of pneumococcal bacteria. Many believe that Avery warranted the Nobel Prize for this discovery. Avery's work is evaluated here in light of the Nobel archives, which have made public the names of those who nominated Avery for this award and the basis for each of the nominations. Based on the archival record, it seems that key biological chemists were not convinced by Avery's claim that DNA was the basis of heredity, that no geneticists nominated Avery, and that most nominators overlooked Avery's work on DNA in favor of his work on the immunogenicity of the bacterial capsule. Three critical scientific factors that adversely affected acceptance of Avery's work were the possibility of protein contamination of DNA, the role of DNA transformation limited to a few species of bacteria, and the possibility that DNA was acting as a chemical mutagen on the true genetic substance. In addition, Avery's own idiosyncratic behavior may have unintentionally confounded acceptance of his groundbreaking discovery.