Does maternal smoking during pregnancy associate recurrent wheezing in infants by altering neonatal serum folate status?

摘要

We read with great interest the recent article by Robison et al.1 whose objective was to evaluate the interactive effects of maternal smoking and prematurity upon the development of early childhood wheezing. They found that maternal smoking in utero and prematurity appear to have a joint effect on recurrent wheezing and an interactive effect on the number of episodes of early childhood wheezing. The authors did not report any conclusion on folic acid supplementation, which might be associated with wheezing and could be affected by maternal smoking.