Change in urinary 8-hydroxydeoxyguanosine in idiopathic nephrotic syndrome

摘要

We read with great interest the article entitled "Antioxidant status of children with idiopathic nephrotic syndrome" by Mishra et al. which was recently published in Pediatric Nephrology [1]. Oxidative stress (OS), defined as a disturbance in the reactive oxygen species (ROS) and antioxidant balance, can result either from low levels of antioxidants and/or from an increased production of ROS. It has been postulated that childhood idiopathic nephrotic syndrome (INS) is associated with OS due to increased levels of ROS and decreased levels of antioxidants [2], although results to the contradictory have been published [3]. Mishra et al. [1] report evidence of OS and impaired antioxidant defense during acute INS.