2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

Herve Geneste; Bernd Schafer

首页> 外文期刊>Synthesis: International Journal of Methods in Synthetic Organic Chemistry >2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

【24h】

2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

机译：定向邻位锂取代2-取代的4-（三氟甲基）苯酚

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A broad variety of 2-substituted 4-(frifluoromethyl)phenols can be prepared in a large scale by o-lithiation and reaction with electrophiles in good to excellent yields. The key for the selectivity is the superior ortho-directing effect of the THP-protected hydroxy group (OTHP) as compared to the CF_3-group.

机译：可以通过邻-锂化和与亲电试剂反应以良好至优异的收率大规模制备各种各样的2-取代的4-（四氟甲基）苯酚。选择性的关键是，与CF_3-基相比，THP保护的羟基（OTHP）具有更好的邻位导向作用。

著录项

来源
《Synthesis: International Journal of Methods in Synthetic Organic Chemistry》 |2001年第15期|共5页
作者
Herve Geneste; Bernd Schafer;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
arylations; electrophilic aromatic substitutions; lithiation; protecting groups; 4-(trifluoromethyl)phenol;

机译：芳基化;亲电芳香取代;锂化;保护基;4-（三氟甲基）苯酚;

相似文献

外文文献
中文文献
专利

1. 2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation [J] . Herve Geneste, Bernd Schafer Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2001,第15期

机译：定向邻位锂取代2-取代的4-（三氟甲基）苯酚
2. Synthesis of halogenated phenols by directed ortho-lithiation and ipso-iododesilylation reactions of O-aryl N-isopropylcarbamates [J] . Kauch M, Hoppe D Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2006,第10期

机译：通过O-芳基N-异丙基氨基甲酸酯的定向邻位锂化和异丙基碘硅烷化反应合成卤代酚
3. A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted MOM protected phenols followed by carboxylation [J] . Stephen Y.W.Lau, Brian A.Keay Canadian Journal of Chemistry . 2001,第11期

机译：通过定向原位锂化或卤素-金属交换取代的MOM保护的酚，然后进行羧化反应，合成3-取代水杨酸的高效策略
4. Crystallographic structure analysis of 4-phenoxy-2-(4-(trifluoromethyl)phenyl) quinazoline [C] . Balbir Kumar, Naresh Sharma, Asif Ali, National Conference on Recent Advances in Experimental and Theoretical Physics . 2018

机译：4-苯氧基-2-（4-（三氟甲基）苯基）喹唑啉的晶体结构分析
5. The directed ortho-lithiation of lithium phenylsulfide and lithium phenylselenide plus sigma-aromaticity and the hexakis(phenylseleno)benzene dication. [D] . Loop, Cynthia Kay. 1990

机译：苯基硫化锂和苯基硒化锂的定向邻位锂化加上sigma-芳香性和六（苯基硒代）苯指示。
6. Regioselective Synthesis of Bis(2-halo-3-pyridyl) Dichalcogenides (E = S Se and Te): Directed Ortho-Lithiation of 2-halopyridines [O] . K. K. Bhasin, Neelam Singh, Shivani Doomra, 2007

机译：双（2-卤-3-吡啶基）双硫属元素化物的区域选择性合成（E = SSe和Te）：2-卤吡啶的定向邻位合成
7. Regioselective Synthesis of Bis(2-halo-3-pyridyl) Dichalcogenides (E = S, Se and Te): Directed Ortho-Lithiation of 2-halopyridines [O] . Bhasin, K. K., Singh, Neelam, Doomra, Shivani, 2007

机译：双（2-卤-3-吡啶基）双硫属元素化物的区域选择性合成（E = S，Se和Te）：2-卤吡啶的定向邻位合成
8. EPA Pesticide Fact Sheet: (CAS) N-(cyanomethyl) -4-(trifluoromethyl) -3-(pyridinecarboximide) or (UPAC) N-cyanomethyl-4-trifluoromethyl nicotinamide (Flonicamid) [R] . 2004

机译：Epa农药事实表：（Cas）N-（氰基甲基）-4-（三氟甲基）-3-（吡啶羧酰亚胺）或（UpaC）N-氰基甲基-4-三氟甲基烟酰胺（Flonicamid）

2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

摘要

著录项

相似文献

相关主题

期刊订阅