A simple and efficient route to chaetomellic anhydride A: A potent natural Ras farnesyl-protein transferase inhibitor

摘要

A new and efficient approach to chaetomellic anhydride A has been devised starting from 2,2-dichloropalmitic acid. This involves the atom transfer radical cyclization of an N-alkyl-N-(3-chloro-2-propenyl)amide followed by rearrangement of the resulting trichloro-pyrrolidin-2-one.