A superior non-symmetrical NCP pincer type palladacycle catalyst precursor for the coupling of aryl boronic acids with aryl chlorides

摘要

The air and water stable non-symmetrical pincer palladacycle [Me2NCH2(Cl)C=C(CH2)(2)OP(i-Pr)(2)-kNkCkP]PdCl 5, easily prepared from the chloropalladation of the hetero-substituted alkyne Me(2)NCH(2)Cequivalent toC(CH2)(2)OP(i-Pr)(2), is a highly efficient catalyst precursor for the coupling of aryl boronic acids and aryl chlorides. Both electron-rich and electron-poor aryl chlorides are efficiently coupled in the presence of 5 to furnish the corresponding cross-coupled products in excellent yields, and a wide variety of functional groups are tolerated in both aryl chloride and aryl boronic acid. [References: 35]