A Novel, One-Pot, Efficient Synthesis of 2-Aroyl-l,4-diaryl-7,9-dimethyl-7,9-diazaspiro(4.5)deca-l,3-diene-6,8,10-triones

摘要

Abstract: A novel and efficient synthesis of 2-aroyl-l ,4-diaryl-7,9-dimethyl-7,9-diazaspiro[4.5]deca-1,3-diene-6,8,10-triones is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of triphenylphosphine to diaroylacetylenes, was trapped by a Knoevenagel condensation product prepared in situ by reaction of N,N-dimethylbarbituric acid and aromatic aldehydes, to afford the title compounds in excellent yields under mild reaction conditions.