Copper-catalyzed aerobic oxidative trifluoromethylation of h-phosphonates using trimethyl(trifluoromethyl)silane

摘要

Copper-catalyzed aerobic oxidative trifluoromethylation of readily accessible H-phosphonates was demonstrated for the first time. This method not only provides an alternative method for the facile synthesis of a series of biologically important CFphosphonates, but also demonstrates the first example of the efficient construction of a P-CFbond via transition-metal catalysis.