A Multicomponent Reaction between alpha-Substituted Acroleins, Nitroalkanes and Paraformaldehyde: Efficient Construction of Nitro delta-Lactol

摘要

A base-catalyzed multicomponent cascade reaction between alpha-substituted acroleins, nitroalkanes, and paraformaldehyde that proceeded smoothly to give high yields of functionalized delta-lac-tols under mild conditions, is described. This methodology is useful in the development of a concise synthetic route to natural products (+-)-manzacidin A and C.