Application of the Horner-Wadsworth-Emmons reaction to the functionalization of dendrimers: Synthesis of amino acid terminated dendrimers

摘要

The Horner-Wadsworth-Emmons reaction of the first, third and fourth generation of aldehyde terminated dendrimers 1-[Gn] (n = 1: 6 CHO, n = 3: 24 CHO, n = 4: 48 CHO groups, respectively) with phosphonates unsubstituted at the carbon alpha to the phosphoryl group 2a-i affords in moderate yield dendrimers bearing various alpha,beta-unsaturated functional groups on the surface, including amino acid derivatives.