Tin-Mediated One-Pot Synthesis of ,-Disubstituted Homoallylic Hydrazides from Ketones, Acylhydrazines and Allyl Bromide

摘要

An efficient multicomponent one-pot reaction was developed for the synthesis of ,-disubstituted homoallylic hydrazides by treating ketones, acylhydrazines and allyl bromide with tin powder in tetrahydrofuran under reflux. The reaction proceeds smoothly without any catalyst under mild conditions to give the corresponding products in high yields.