Unusual Ring Closure Reaction of Amides with Pyrimidines: Novel Stereoselective Synthesis of Hexahydroimidazo[1,2-c]pyrimidines

摘要

Hexahydromidazo[1,2-c]pyrimidines 6 were prepared by the reaction of tosylpyrimidines 2 with bromoacetamides 3 in one step. The stereoselectivity of the reaction has been confirmed by X-ray analysis. Imidazo[1,2-a]pyrimidines 5 were obtained on heating hexahydroimidazo[1,2-c]pyrimidines 6 with trifluoroacetic anhydride.