Facile synthesis of spiro[indane-2,1′-pyrrolo[2,1-a ]isoquinolines] via three-component reaction of isoquinolinium salts, indane-1,3-dione, and isatins

摘要

A series of novel 2′-aryl-2′-(2-oxo-1,2-dihydro-3H-indol-3- ylidene)-2′,3′-dihydro-10b′H-spiro[indene-2, 1′-pyrrolo[2,1-a]isoquinoline]-1,3-diones were efficiently synthesized by three-component reactions of in situ generated N-phenacylisoquinolinium bromides with indane-1,3-dione and isatins in ethanol with triethylamine as the base. A domino reaction mechanism for the formation of the spiro compounds was rationally proposed.