Synthesis of 6,6'-Diamino-2,2'-biquinoline and 2,2'-Bi-1,6-naphthyridine

摘要

High-yield synthesis and characterization of the new heterocycles 6,6'-diamino-2,2'-biquinoline (3), 6,6'-bis(N, N-dimethylamino)-2,2'-biquinoline (4), and 2,2'-bi-1,6-naphthyridine (5) are described. The preparation of 3 and 4 is based on the coupling of 2-amino-6-chloroquinoline and 2-chloro-6-dimethylaminoquinoline in the presence of NiCl_2 centre dot 6H_2O/PPh_3/Zn in DMF (NiCRA). Compound 5 was synthesized through a condensation reaction of 4-aminopyridine-3-carbaldehyde and butane-2,3-dione.