首页> 外文期刊>Synthesis: International Journal of Methods in Synthetic Organic Chemistry >Palladium-catalyzed, microwave-assisted synthesis of 3,4-dihydro-3-oxo-2 H -1,4-benzoxazines: An improved catalytic system and multicomponent process
【24h】

Palladium-catalyzed, microwave-assisted synthesis of 3,4-dihydro-3-oxo-2 H -1,4-benzoxazines: An improved catalytic system and multicomponent process

机译:钯催化的微波辅助合成3,4-二氢-3-氧代-2 H -1,4-苯并恶嗪:改进的催化体系和多组分工艺

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

An improved palladium-catalyzed system is established for the synthesis of 3,4-dihydro-3-oxo-2H-1,4-benzoxazines from less reactive ethyl 2-(2-chlorophenoxy)alkanoates and aryl amines under controlled microwave heating, employing 2-dicyclohexylphosphino-2′,4′,6′- triisopropylbiphenyl (XPhos) as the ligand. Moreover, a high-yielding, three-component reaction protocol is disclosed for the efficient one-pot synthesis of 3,4-dihydro-3-oxo-2H-1,4-benzoxazines from 2-halophenols, ethyl 2-bromoalkanoates, and aryl amines. Microwave heating at high temperature is necessary to achieve high yields with 2-chlorophenol. A wide range of substrates is tolerated affording the desired products in good to excellent yields.
机译:建立了一种改进的钯催化体系,用于在控制的微波加热下,由反应性较低的2-(2-氯苯氧基)链烷酸乙酯和芳基胺合成3,4-二氢-3-氧代-2H-1,4-苯并恶嗪。 2-二环己基膦基-2',4',6'-三异丙基联苯(XPhos)作为配体。此外,公开了一种高产率的三组分反应方案,用于由2-卤代酚,2-溴链烷酸乙酯和三氟乙烷有效地一锅合成3,4-二氢-3-氧代-2H-1,4-苯并恶嗪。芳基胺。为了获得2-氯苯酚的高收率,必须进行高温微波加热。可以耐受各种各样的底物,以高到极好的产量提供所需的产品。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号