Studies toward the synthesis of iejimalides A-D: Preparation of the C3-11 and C12-C24 fragments

摘要

The convergent synthesis of the C3-C11 and C12-C24 fragments of the iejimalides A-D is described. The C3-C11 fragment is obtained by a cross-metathesis reaction, while the C12-C24 fragment is derived from a Still-Gennari modified Horner-Wadsworth-Emmons olefination.