One-pot synthesis of pentasubstituted pyrroles from propargylic alcohols, amines, and dialkyl acetylenedicarboxylates; Tandem amination, propargylation and cycloisomerization catalyzed by molecular iodine

摘要

A multicomponent one-pot synthesis of fully substituted pyrroles has been developed by the tandem reaction of amines, dialkyl acetylenedicarboxylates, and propargylic alcohols using iodine as a catalyst. The reaction was complete in three hours and afforded the products in high yields (75-88%). The method is simple, efficient, cost-effective, and metal-free.