Synthesis, spectroscopic, DNA binding, and antimicrobial studies on bis (1-amidino-O-alkylurea) Cu(II) tartrate complexes where alkyl = methyl, ethyl, n-propyl, n-, or iso-butyl

摘要

Five New Cu(II) complexes, [bis(1-amidino-O-alkylurea) Cu(II)tartrate], where alkyl= methyl (1), ethyl (2), n-propyl (3), n-butyl (4), or iso-butyl (5) have been synthesized and characterized. The electron paramagnetic resonance spectra of complexes 1 and 2 showed features of mononuclear species whereas complexes 3, 4, and 5 in frozen DMSO solution show the existence of mononuclear and binuclear species in these complexes. Complexes crystallize in a monoclinic structure. The binding of these complexes with calf thymus DNA suggested that these complexes interact with DNA by electrostatic or groove binding, not by intercalation. These complexes are also found to have good antimicrobial activity.