SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR ACTIVITY OF PLATINUM(II) COMPLEXES OF MIXED AMMINE/AMINE WITH BIDENTATE CARBOXYLATES

摘要

Complexes of the type Pt(II)(CH_3NH_2)(NH_3)((OC)_2-(CH_2)_n)·0.5H_2O ((1)-(3)) (n = 0, 1 and 2) have been synthesized for the first time. At the same time, we also have synthesized three precursor complexes. They were characterized by elemental analyses, molar conductance, differential thermal analyses and spectral (IR, UV, ~1H NMR) studies. In vitro antitumor activity results indicate that these complexes have significant activity against HL-60 and U937, but show poor activity against K562, (HL-60, U937 and K562 are human leukemic tumor cell lines).