SbCl5/SiO2 Nanoparticles: An Efficient and Reusable Reagent for the Synthesis of 4,4 '-(Arylmethylene)bis(1H-pyrazol-5-ol) Derivatives in Water

摘要

An efficient and eco-friendly method for the synthesis of 4,4 '-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives is described by tandem Knoevenagel-Michael reaction between aromatic aldehydes and 3-methyl-1-phenyl-2-pyrazoline-5-one in the presence of nanosilica supported antimony pentachlorid (SbCl5/SiO2 NPs) in water. This method provides several advantages such as environmental friendliness, shorter reaction time, waste free, simple workup, and excellent yields.