The pragmatic use of apomorphine at the end of life.

Dewhurst F; Lee M; Wood B

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The pragmatic use of apomorphine at the end of life.

机译：在生命的尽头务实使用阿扑吗啡。

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Parkinson's Disease (PD) is an irreversible degenerative neurological disorder with no known cure. Apomorphine is a potent short-acting D1/D2 dopamine agonist administered sub-cutaneously that is used in the treatment of PD. Optimising PD medication is an important aspect of end of life care. There are no previously reported cases of apomorphine providing symptom relief in terminal care of PD patients. This case highlights its potential benefits for symptom control at the end of life.

机译：帕金森氏病（PD）是一种不可逆的变性神经系统疾病，目前尚无治愈方法。阿扑吗啡是皮下给药的强效短效D1 / D2多巴胺激动剂，用于治疗PD。优化PD药物治疗是生命周期终止护理的重要方面。以前没有报道阿扑吗啡在PD患者的终末治疗中可缓解症状。该案例突出了其生命终结期对症状控制的潜在益处。

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《Palliative medicine 》 |2009年第8期| 共3页
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Dewhurst F; Lee M; Wood B;
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正文语种 eng
中图分类治疗学 ;
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1. The pragmatic use of apomorphine at the end of life. [J] . Dewhurst F, Lee M, Wood B Palliative medicine . 2009 ,第8期

机译：在生命的尽头务实使用阿扑吗啡。
2. ERK activation in the prefrontal cortex by acute apomorphine and apomorphine conditioned contextual stimuli [J] . Sanguedo Frederico Velasco, Figueiredo Amanda Machado, Carey Robert J., Pharmacology, Biochemistry and Behavior . 2017 ,第期

机译：ERK活化在急性阿托啡啡和扑梅定条件的前额叶皮质中的激活
3. A Protocol for Induction of Tolerance to Apomorphine in Patients With Parkinson Disease and Hypersensitivity to Apomorphine [J] . Gutiérrez-Fernández D, Moreno-Ancillo A, Foncubierta-Fernández A, Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologie . 2016 ,第5期

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4. Apomorphine-susceptible and apomorphine-imsusceptible rats as model for High-resisting and Low-resisting pigs: Metabolic differences [C] . S.B. Degen, M.W.P. Hof, W.J.J. Gerrits, Joint Symposium on Energy and Protein Metabolism and Nutrition . 2003

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6. Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease [O] . Felix Agbo, Ryan L. Crass, Yu‐Yuan Chiu, 2021

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机译：帕金森病患者Abomerphine舌下胶片和皮下扑梅啡配方的药代动力学和对比生物利用度和“关闭”集：随机，三通交叉，开放标签研究的结果

The pragmatic use of apomorphine at the end of life.

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