N-glycosylation in Bacteria and Eukaryotes

摘要

The decoration of proteins with carbohydrates on specified asparagine side chains(= protein N-glycosyl-ation)is an essential process in eukaryotic cells.A homologous pathway was identified in the bacterium Campylobacter jejuni.The functional transfer of the glycosylation pathway into Escherichia coli cells allows for a detailed analysis and a comparison to the eukaryotic process.Generally similar,there are fine but relevant differences.This article discusses the common principles and the variations of bacterial and eukaryotic N-glyco-slyation as well as the potential use of the bacterial system to produce novel glycoconjugates.