Flavanoids and Pterocarpans from the Bark of Erythrina fusca

摘要

Three new isomeric flavanones, fuscaflavanones A, (1), A2 (2) and B (3), together with six known flavanones,lupinifolin (4), lonchocarpol A (5), a mixture of lonchocarpols C, and C2 (6a, b), and a mixture of lonchocarpolsD, and D2 (7a, b), five pterocarpans, sandwicensin (8), phaseollidin (9), erythrabissin I (10), and a mixture ofdolichins A and B (11a, b), one chalcone, isobavachalcone (12), and one isoflavone, wighteone (13), were isolatedfrom the bark of Erythrina fusca LOUR. Their structures were elucidated on the basis of spectroscopic data. Someisolates were tested for antiplasmodial and cytotoxic activities and it was found that 5 and 9 exhibited moderateantiplasmodial activity against Plasmodium falciparum. For cytotoxicity, compounds 1, 4, 5, 9 and 12 showedmoderate to weak activity against KB, BC and NCI-H187 cells, whereas 2 exhibited only weak activity againstKB cells.