Suicidality associated with antiepileptic drugs: Implications for the treatment of neuropathic pain and fibromyalgia

摘要

Antiepileptic drugs (AEDs) have a prominent role in the treatment of several types of chronic pain. Gabapentin and pregabalin are recommended as first-line treatments for various neuropathic pain conditions, carbamazepine and oxcarbazepine are commonly used in trigeminal neuralgia, and certain AEDs are considered second- or third-line treatments for neuropathic pain [3,7,11,12,25]. In addition, pregabalin is recommended for flbromyalgia [8], and topiramate and valproic acid are considered first-line treatments for migraine prophylaxis [13,331.