A concise route to the key intermediate of (+)-vernolepin using a bicyclo [3.2.1]octane chiral building block

摘要

An enantioselective route to the key intermediate leading to (+)-vernolepin. an antitumor sesquiterpene. isolated from Vernonia hymenolepis, has been developed starting from the chiral building block having a bicyclo[3.2.1]octane framework accessible by either enzymatic or catalytic kinetic resolution. [References: 29]