Synthesis of novel chiral phosphine-olefin complexes and their evaluation as ligands in the rhodium-catalyzed asymmetric 1,4-addition

摘要

Novel chiral phosphine-olefin complexes containing ferrocene and cyrhetrene backbones have been synthesized and evaluated as ligands in the rhodium-catalyzed 1,4-addition of phenylboronic acid to cyclohexenone. The highest efficiency in this series was observed with planar-chiral ligands 5a and 20, which furnished the corresponding product with up to 71% ee.